Description

Cyclotheonamide A is a potent and selective cyclic peptide serine protease inhibitor originally isolated from marine sponges. This compound is of significant interest in biochemical and pharmacological research due to its unique mechanism of action, which involves covalent modification of the active site. It serves as a critical tool for researchers in enzymology, drug discovery, and molecular biology, particularly for studying thrombin and other trypsin-like proteases.

Application

• Biochemical Research: As a selective, irreversible inhibitor for studying the structure, function, and inhibition kinetics of serine proteases like thrombin, trypsin, and plasmin.
• Drug Discovery & Development: A valuable lead compound and pharmacological probe for designing novel anticoagulant and anti-inflammatory therapeutics.
• Enzymology Studies: Used to elucidate enzyme mechanisms and active site interactions due to its covalent binding properties.
• Protease Assay Development: Employed as a reference standard and control in high-throughput screening (HTS) assays to identify new protease inhibitors.
• Academic & Pharmaceutical R&D: Essential for basic research in universities, government labs, and biopharmaceutical companies focused on hemostasis, thrombosis, and related pathways.

Basic Information

Product Name	Cyclotheonamide A
CAS No.	129033-04-1
Molecular Formula	C34H49N7O7
Molecular Weight	667.80 g/mol
Synonyms	Cyclotheonamide A; Cyclotheonamide-A; Theonellamide F (Note: Often associated but structurally distinct); Marine sponge cyclic peptide; Serine protease inhibitor peptide; Thrombin inhibitor peptide; Contact for details on additional research codes and identifiers.
EINECS	Contact for details

Quality Control

Our Cyclotheonamide A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to relevant standards for research-grade biochemicals, ensuring material integrity for sensitive experimental work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.