Description

Isovaleryl-Valyl-Valyl-Statine Phosphinate Ethyl Ester is a specialized synthetic peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a potent and selective inhibitor of aspartic proteases, making it a critical tool for studying enzymatic pathways and disease mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for targeting conditions like hypertension, Alzheimer's disease, and viral infections such as HIV.

Application

• Protease Inhibition Research: Acts as a key biochemical tool for studying the function and inhibition of aspartic proteases like renin, pepsin, and HIV-1 protease.
• Pharmaceutical Intermediate: Serves as a sophisticated building block or precursor in the synthesis of novel therapeutic agents targeting cardiovascular and neurological disorders.
• Enzyme Mechanism Studies: Used in kinetic and structural studies to elucidate substrate binding and catalytic mechanisms of target enzymes.
• High-Throughput Screening (HTS): Employed as a reference standard or positive control in assays designed to discover new protease inhibitors.
• Bioconjugation & Probe Development: Can be functionalized to create activity-based probes for proteomic profiling and diagnostic applications.

Basic Information

Product Name	Isovaleryl-Valyl-Valyl-Statine Phosphinate Ethyl Ester
CAS No.	128901-52-0
Molecular Formula	C27H51N4O7P
Molecular Weight	574.69 g/mol
Synonyms	Isovaleryl-Val-Val-Sta(P)(O)Et; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoyl-L-valyl-N-[(1S)-3-methyl-1-[[(2-methylpropanoyl)amino]methyl]butyl]-L-valinamide Phosphinic Acid Ethyl Ester; Statine Phosphinate Derivative; Aspartic Protease Inhibitor; Renin Inhibitor Analog; IVV-Sta(P)(O)Et; Peptidomimetic Phosphinate
EINECS	Contact for details

Quality Control

Every batch of Isovaleryl-Valyl-Valyl-Statine Phosphinate Ethyl Ester is subjected to rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA), detailing results from HPLC, NMR, and MS analyses, is provided with each shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.