Description

Acetyl-Phenylalanyl Trifluoromethyl Ketone is a specialized synthetic peptide derivative and a potent, irreversible inhibitor of serine proteases. This compound is valued for its high selectivity and efficacy in biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for enzyme mechanism studies and as a key intermediate in drug discovery programs.

Application

• Protease Inhibition Research: Serves as a critical tool compound for studying the activity and inhibition mechanisms of serine proteases like chymotrypsin and elastase.
• Pharmaceutical Intermediate: Used in the synthesis and development of novel therapeutic agents targeting protease-related diseases.
• Biochemical Assay Development: Employed as a standard or reference inhibitor in high-throughput screening (HTS) and enzymatic assay kits.
• Academic & Institutional Research: Supports fundamental research in biochemistry, molecular biology, and medicinal chemistry at universities and R&D institutes.
• Peptide Chemistry Studies: Acts as a model compound for investigating the structure-activity relationships (SAR) of peptide-based inhibitors.

Basic Information

Product Name	Acetyl-Phenylalanyl Trifluoromethyl Ketone
CAS No.	128656-63-3
Molecular Formula	C13H14F3NO3
Molecular Weight	289.25 g/mol
Synonyms	Ac-Phe-CF3; N-Acetyl-L-phenylalanine trifluoromethyl ketone; Acetylphenylalanyl trifluoromethyl ketone; (S)-2-Acetamido-3-phenyl-1-(trifluoromethyl)propan-1-one; L-Phenylalanine, N-acetyl-, 1-(trifluoromethyl)-1-oxoethyl ester; Protease Inhibitor Ac-Phe-CF3; Chymotrypsin Inhibitor Ac-Phe-CF3
EINECS	Contact for details

Quality Control

Our Acetyl-Phenylalanyl Trifluoromethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee consistent quality and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.