Description

Calpain Inhibitor Peptide is a potent and selective synthetic peptide designed to inhibit the activity of calpain proteases. This compound is a critical research tool for studying the role of calpains in cellular processes such as apoptosis, signal transduction, and neurodegenerative diseases. It is primarily utilized by researchers and scientists in the fields of neuroscience, cell biology, and pharmaceutical development for both in vitro and in vivo applications.

Application

• Biomedical Research: Fundamental research into calpain-mediated pathways in cellular function and disease models.
• Neurodegenerative Disease Studies: Investigation of calpain's role in conditions like Alzheimer's disease, Parkinson's disease, and traumatic brain injury.
• Apoptosis & Cell Death Research: Used as a specific inhibitor to elucidate mechanisms of programmed cell death.
• Signal Transduction Analysis: Tool for dissecting calcium-dependent signaling cascades where calpains are involved.
• Pharmaceutical Screening: Serves as a reference compound or positive control in high-throughput screening for novel calpain inhibitors.
• Biochemical Assay Development: Key component in establishing and validating enzymatic assays for calpain activity.

Basic Information

Product Name	Calpain Inhibitor Peptide
CAS No.	128578-18-7
Molecular Formula	C20H37N5O7
Molecular Weight	459.54 g/mol
Synonyms	N-Acetyl-Leu-Leu-Nle-CHO; ALLN; Calpain Inhibitor I; MDL 28170; Ac-LLNle-CHO; N-Acetyl-Leu-Leu-Norleucinal; Calpeptin analog; Protease Inhibitor ALLN
EINECS	Contact for details

Quality Control

Our Calpain Inhibitor Peptide is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to rigorous internal quality standards to guarantee product integrity. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90% inhibitory activity
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.