Description

(2-Hydroxypropyl)-γ-Cyclodextrin is a chemically modified derivative of γ-cyclodextrin, engineered to enhance solubility and stability for complexation with a wide range of guest molecules. This modification is critical for improving the bioavailability and delivery of poorly soluble active ingredients in pharmaceutical and nutraceutical formulations. It serves as an essential solubilizing and stabilizing agent for researchers and manufacturers in the pharmaceutical, cosmetic, and food science industries seeking advanced delivery solutions.

Application

• Pharmaceutical Solubilization & Delivery: Enhances the aqueous solubility, stability, and bioavailability of poorly soluble APIs in oral, topical, and injectable formulations.
• Drug Encapsulation: Forms inclusion complexes to protect sensitive drugs from degradation (e.g., oxidation, hydrolysis) and mask unpleasant tastes or odors.
• Cosmetic & Personal Care: Used to stabilize fragrances, vitamins, and active ingredients in creams, lotions, and serums, improving skin penetration and product shelf-life.
• Food & Nutraceutical Ingredient: Acts as a carrier for flavors, colors, vitamins, and supplements, improving their stability in food matrices and beverages.
• Analytical Chemistry & Research: Employed as a chiral selector in capillary electrophoresis and HPLC for enantiomer separation, and as a tool in biochemical studies.
• Chemical Synthesis & Catalysis: Functions as a green, water-soluble host in supramolecular chemistry to facilitate reactions and modify reagent properties.

Basic Information

Product Name	(2-Hydroxypropyl)-γ-Cyclodextrin
CAS No.	128446-34-4
Molecular Formula	CnHmOx (Hydroxypropylated γ-Cyclodextrin)
Molecular Weight	Variable (depends on degree of substitution). Contact for details.
Synonyms	Hydroxypropyl γ-Cyclodextrin; HP-γ-CD; 2-HP-γ-CD; γ-HPCD; (2-HP)-γ-CD; Hydroxypropyl-γ-cyclodextrin; 2-Hydroxypropyl-γ-cyclodextrin; Heptakis(2-hydroxypropyl)-γ-cyclodextrin (partial substitution)
EINECS	Contact for details.

Quality Control

Our (2-Hydroxypropyl)-γ-Cyclodextrin is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and purity. Specifications are aligned with industry requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, degree of substitution, and residual solvent levels is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-γ-CD)	≥ 98.0% (on dried basis)
Degree of Substitution (Molar)	0.6 - 1.2 (or as specified)
Water Content (Karl Fischer)	≤ 5.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Microbial Limits	Meets standard criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.