Description

2-Hydroxypropyl-α-Cyclodextrin is a chemically modified derivative of α-cyclodextrin, engineered to enhance solubility and stability for complexation with a wide range of guest molecules. This compound matters for its exceptional ability to improve the bioavailability, stability, and delivery of active ingredients in pharmaceutical and nutraceutical formulations. It is primarily needed by manufacturers in the pharmaceutical, food, and cosmetic industries seeking advanced solubilization and encapsulation solutions.

Application

• Pharmaceutical Solubilizer & Stabilizer: Enhances the aqueous solubility and chemical stability of poorly soluble active pharmaceutical ingredients (APIs) in oral, topical, and injectable formulations.
• Drug Delivery Systems: Used as a functional excipient in controlled-release systems and to improve drug bioavailability.
• Food & Flavor Industry: Encapsulates and protects sensitive flavors, colors, and nutrients from oxidation and degradation, masking undesirable tastes.
• Cosmetic & Personal Care: Serves as a carrier for fragrances and active ingredients in creams and lotions, improving skin penetration and formulation stability.
• Analytical Chemistry: Employed as a chiral selector in capillary electrophoresis and HPLC for the separation of enantiomers.
• Biotechnology & Research: Used to solubilize membrane proteins and cholesterol in cell culture and biochemical assays.

Basic Information

Product Name	2-Hydroxypropyl-α-Cyclodextrin
CAS No.	128446-33-3
Molecular Formula	CnH2nOn (Hydroxypropyl-substituted)
Molecular Weight	~1135 g/mol (Average, depends on degree of substitution)
Synonyms	HP-α-CD; Hydroxypropyl Alpha Cyclodextrin; 2-HP-α-CD; α-Cyclodextrin, 2-hydroxypropyl ether; Kleptose® HPB; Cavasol® W6 HP; (2-Hydroxypropyl)-α-cyclodextrin
EINECS	Contact for details

Quality Control

Our 2-Hydroxypropyl-α-Cyclodextrin is manufactured under a quality management system. Each batch is tested to ensure it meets stringent specifications for identity, purity, and performance. Certificates of Analysis (COA) detailing key parameters such as degree of substitution, assay, and residue solvents are provided to guarantee compliance with your application requirements, including potential use under cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-α-CD)	≥ 98.0% (on dried basis)
Degree of Substitution (Molar)	0.6 - 1.0 (Typical, customizable)
Loss on Drying	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Residual Solvents	Meets ICH guidelines
Microbiological Count	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.