Description

Boc-Dl-Buthioninesulfoximine is a protected derivative of the metabolic inhibitor buthionine sulfoximine (BSO), designed for enhanced stability and handling in research applications. This compound is a critical tool for selectively inhibiting glutathione synthesis, enabling the study of oxidative stress, cancer cell resistance, and cellular detoxification pathways. It is primarily utilized by pharmaceutical researchers, academic biochemists, and contract research organizations (CROs) focused on oncology, neurobiology, and toxicology.

Application

• Biochemical Research: A key reagent for studying the role of glutathione (GSH) in cellular redox balance and apoptosis.
• Oncology Research: Used to sensitize cancer cells to chemotherapy and radiotherapy by depleting intracellular glutathione levels.
• Neuropharmacology Studies: Employed in models of neurodegenerative diseases to investigate oxidative damage mechanisms.
• Toxicology Screening: Serves as a standard inhibitor in assays evaluating drug metabolism and hepatotoxicity.
• Peptide Synthesis Intermediate: The Boc-protected amino acid moiety can be utilized in solid-phase peptide synthesis (SPPS).
• Cell Culture & In Vitro Studies: Applied in media to create glutathione-deficient conditions for functional genomics and proteomics research.

Basic Information

Product Name	Boc-Dl-Buthioninesulfoximine
CAS No.	128377-41-3
Molecular Formula	C₁₃H₂₆N₂O₅S
Molecular Weight	322.42 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-DL-buthionine sulfoximine; BOC-DL-BSO; tert-Butyloxycarbonyl-DL-buthionine sulfoximine; (RS)-2-Amino-4-((S)-carboxy(hydroxy)methylamino)-4-oxobutyl](tert-butoxy)carbamic acid; BOC-Buthionine Sulfoximine; DL-Buthionine-(S,R)-sulfoximine, N-BOC-protected; N-Boc-DL-buthionine sulfoximine; N-tert-Butoxycarbonyl-DL-buthionine sulfoximine
EINECS	Contact for details

Quality Control

Our Boc-Dl-Buthioninesulfoximine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for fine chemicals and can provide material for research use under GMP-like controls upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain quality. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Purity (Chiral HPLC)	DL-mixture
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.