Description

4-Hydroxytamoxifen β-Glucuronide is a key metabolite and analytical reference standard of the selective estrogen receptor modulator (SERM) tamoxifen. This compound is critical for pharmaceutical research and development, particularly in the study of tamoxifen metabolism, pharmacokinetics, and drug monitoring. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology drug development and bioanalytical method validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of tamoxifen and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the Phase II conjugation pathway (glucuronidation) of 4-hydroxytamoxifen, a major active metabolite.
• Bioanalytical Method Development: Used as a critical standard in LC-MS/MS and HPLC-UV method development and validation for therapeutic drug monitoring (TDM) in breast cancer patients.
• Clinical Research: Employed in studies correlating metabolite levels with therapeutic efficacy and side-effect profiles of tamoxifen therapy.
• Biochemical Research: Used in *in vitro* assays to study the activity and inhibition of UDP-glucuronosyltransferase (UGT) enzymes.
• Quality Control: Acts as an impurity standard in the quality control of tamoxifen active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Item	Detail
Product Name	4-Hydroxytamoxifen β-Glucuronide
CAS No.	128255-45-8
Molecular Formula	C34H41NO10
Molecular Weight	623.69 g/mol
Synonyms	4-Hydroxytamoxifen Glucuronide; (Z)-4-Hydroxytamoxifen β-D-Glucuronide; 4-OHT-Gluc; NSC 108041; Tamoxifen Metabolite Y; β-Glucuronide of 4-Hydroxytamoxifen; 1-{4-[2-(Dimethylamino)ethoxy]phenyl}-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxytamoxifen β-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for use as a reference standard. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to prevent condensation. The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.