Description

Calicheamicin Epsilon is a potent enediyne antitumor antibiotic belonging to the calicheamicin family. This compound is of significant interest for its role as a key structural component and precursor in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is primarily utilized by pharmaceutical researchers, biotech companies, and advanced chemical manufacturers engaged in the synthesis of novel chemotherapeutic agents and payloads for targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as a critical warhead or precursor in the construction of highly potent ADCs designed for targeted cancer treatment.
• Pharmaceutical Research & Development: Used as a reference standard and building block in the discovery and development of new enediyne-based anticancer drugs.
• Biochemical Research: Employed in studies investigating DNA cleavage mechanisms and the biological activity of enediyne antibiotics.
• Oncology Drug Discovery: Acts as a key intermediate for the synthesis of novel chemotherapeutic agents with potent cytotoxic activity.
• Process Development & Scale-up: Supplied to support the optimization and manufacturing processes for advanced therapeutic compounds.

Basic Information

Product Name	Calicheamicin Epsilon
CAS No.	128050-91-9
Molecular Formula	C55H74IN3O21S4
Molecular Weight	1368.33 g/mol
Synonyms	Calicheamicin ε; Calicheamicin epsilon; Antibiotic LL-E33288 epsilon; LL-E33288 epsilon; NSC D640214; (1S,2R,3S,7S,8S,10S,11S,14R,16S,18S,19S,20R,21S,22R,24S,26S,27S,28R,29S,30S,31R,32S,33S,34R,35S,36S,37S,38R,39S,40S,41S,42R,43S,44S,45S,46S,47S,48R,49S,50S,51S,52R,53S,54S,55S)-55-[(2R,3S,4S,5S,6R)-4-Acetamido-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-20,30,33,38,41,44-hexahydroxy-19,28,31,34,37,40,43,46,49,52,54-undecaoxo-29,48-bis(sulfanyl)-17,39-dithia-2,4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56-octacosazatricyclo[25.25.0.03,7]hexapentacontane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Calicheamicin Epsilon is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. The product is hygroscopic and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.