Description

Substance P (6-11), Glu(Glc)(6)- is a specific, glycosylated fragment of the neuropeptide Substance P. This modified peptide is of significant interest in advanced biochemical and pharmacological research due to its role in studying receptor-ligand interactions and signal transduction pathways. It is primarily utilized by research institutions and pharmaceutical development teams focused on neuroscience, immunology, and glycobiology.

Application

• Neuroscience Research: Used as a tool compound to study the structure-activity relationship (SAR) of Substance P and its interaction with neurokinin receptors (NK1R).
• Glycobiology Studies: Serves as a model peptide for investigating the effects of O-glycosylation (glucosylation) on peptide stability, bioavailability, and biological activity.
• Immunological Assays: Employed in research exploring the modulation of inflammatory responses and neuro-immune communication.
• Pharmaceutical R&D: Acts as a key intermediate or reference standard in the development of novel peptide-based therapeutics targeting pain, inflammation, and central nervous system disorders.
• Biochemical Reagent: Utilized in enzyme studies, cell signaling experiments, and as a substrate for glycosyltransferase assays.

Basic Information

Product Name	Substance P (6-11), Glu(Glc)(6)-
CAS No.	128022-96-8
Molecular Formula	C41H66N12O16S
Molecular Weight	991.1 g/mol
Synonyms	Substance P Fragment 6-11, O-Glucosylated; [Glc(O)6]-Substance P (6-11); H-Phe-Phe-Gly-Leu-Met-NH2 (6-O-β-D-Glucosyl-Glu); Glucosylated SP(6-11); Neurokinin P (6-11) fragment, Glu(Glc)6; Arg-Pro-Lys-Pro-Gln-Gln(β-D-Glcp)-Phe-Phe-Gly-Leu-Met-NH2 (fragment 6-11); Glycosylated Substance P analog
EINECS	Contact for details

Quality Control

Every batch of Substance P (6-11), Glu(Glc)(6)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and mass spectrometry data are provided with each shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.