Description

Discodermolide CAS NO 127943-53-7 is a complex polyketide natural product originally isolated from the marine sponge *Discodermia dissoluta*. This compound is of significant interest due to its potent microtubule-stabilizing and anti-mitotic properties, functioning as a powerful cytostatic agent. It is primarily utilized in advanced pharmaceutical research and development, particularly in the fields of oncology and chemical biology for studying tubulin dynamics and developing novel chemotherapeutic candidates.

Application

• Oncology Research: As a potent microtubule-stabilizing agent for studying cancer cell proliferation, apoptosis, and mechanisms of drug resistance.
• Chemical Biology Probe: Used as a molecular tool to investigate tubulin polymerization dynamics, cytoskeleton function, and cell cycle regulation.
• Lead Compound Development: Serves as a high-value scaffold and reference standard in the discovery and structure-activity relationship (SAR) studies of novel anti-cancer agents.
• Preclinical Studies: Employed in *in vitro* and *in vivo* models to evaluate efficacy, pharmacokinetics, and toxicity profiles of tubulin-targeting therapies.
• Pharmaceutical Intermediates: Acts as a critical intermediate in the synthetic and semi-synthetic production of complex bioactive molecules.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in marine natural product chemistry and pharmacology.

Basic Information

Product Name	Discodermolide
CAS No.	127943-53-7
Molecular Formula	C33H55NO8
Molecular Weight	593.79 g/mol
Synonyms	(+)-Discodermolide; NSC 609395; Discodermolide, (+)-; (1S,2R,3S,4R,7S,9S,10S,12R,14S,15E,17S,18S,19S,20R)-19-(Acetylamino)-4,7,18-trihydroxy-1,14-dimethoxy-10,12,20-trimethyl-17-[(1E)-1-methyl-2-oxo-2-[(2R,3R)-3-methyl-5-oxo-2-tetrahydrofuranyl]ethenyl]-3,8,21-trioxa-16-azabicyclo[15.2.1]icosa-15(20),18-diene-2,9-dione
EINECS	Contact for details

Quality Control

Our Discodermolide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for handling high-potency active pharmaceutical ingredients (HPAPIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.