Description

2'-(Difluoromethoxy)Acetophenone 98 is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethoxy group, which is critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: Functions as an electrophilic coupling partner in palladium-catalyzed reactions like the Suzuki-Miyaura cross-coupling.
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and effects of fluorinated alkoxy groups in complex molecular architectures.

Basic Information

Product Name	2'-(Difluoromethoxy)Acetophenone 98
CAS No.	127842-55-1
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-[2-(Difluoromethoxy)phenyl]ethan-1-one; 2'-Difluoromethoxyacetophenone; 2-Acetylphenyl difluoromethyl ether; α,α-Difluoro-2-methoxyacetophenone; (2-Difluoromethoxyphenyl)methyl ketone; o-(Difluoromethoxy)acetophenone; DFMA
EINECS	Contact for details

Quality Control

Our 2'-(Difluoromethoxy)Acetophenone 98 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure it meets the specified 98% minimum purity and consistent impurity profile. Certificates of Analysis (COA) detailing all quality parameters are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.