Description

11-Deoxy-4,4-Dimethyl-4-Silaprostaglandin E1 is a specialized silicon-containing prostaglandin analog, a key synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its structural role in creating novel therapeutic agents, particularly in the fields of ophthalmology and dermatology, where prostaglandin pathways are targeted. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on innovating drug candidates and high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel prostaglandin-based drug candidates.
• Ophthalmic Research: Used in the development of new treatments for conditions like glaucoma, leveraging the prostaglandin pathway.
• Dermatological R&D: Investigated for applications in formulations targeting skin conditions and promoting hair growth.
• Chemical Biology Studies: Serves as a probe or tool compound to study prostaglandin receptor interactions and signaling mechanisms.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex bioactive molecules.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	11-Deoxy-4,4-Dimethyl-4-Silaprostaglandin E1
CAS No.	127760-15-0
Molecular Formula	C23H42O4Si
Molecular Weight	410.67 g/mol
Synonyms	4,4-Dimethyl-4-sila-11-deoxyprostaglandin E1; 11-Deoxy-4,4-dimethyl-4-silaprostaglandin E1; 4-Silaprostaglandin E1, 11-deoxy-4,4-dimethyl-; 4,4-Dimethyl-4-sila-PGE1 (11-deoxy); (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(3S)-3-hydroxy-5,5-dimethyl-6-oxa-5-sila-1-octen-1-yl]-5-oxocyclopentyl]-5-heptenoic Acid; Silicon Prostaglandin Analog; Silaprostaglandin Intermediate
EINECS	Contact for details

Quality Control

Our 11-Deoxy-4,4-Dimethyl-4-Silaprostaglandin E1 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (NMR, IR, MS), and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.