Description

(+/-)5(6)-Epoxy-8Z,11Z,14Z,17Z-Eicosatetraenoic Acid, Methyl Ester is a specialized eicosanoid derivative, specifically a methyl ester of an epoxy-eicosatetraenoic acid (EET) regioisomer. This compound serves as a critical intermediate and reference standard in biochemical research for studying the cytochrome P450 (CYP) metabolic pathway of arachidonic acid. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who are investigating inflammation, vascular biology, and developing novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a high-purity reference material in analytical laboratories for the identification and quantification of endogenous EETs.
• Pharmaceutical R&D: Serves as a key intermediate in the synthesis of novel drug candidates targeting epoxide hydrolase or designed to mimic EET activity for cardiovascular and anti-inflammatory applications.
• Metabolic Pathway Studies: Essential for in vitro and in vivo studies to elucidate the biological roles and signaling mechanisms of cytochrome P450-derived eicosanoids.
• Enzyme Activity Assays: Employed as a substrate in assays to measure the activity of soluble epoxide hydrolase (sEH) and other related enzymes.
• Cell Signaling Research: Used to investigate the effects of EETs on ion channels, gene expression, and cellular proliferation in various disease models.
• Production of Analytical Kits: Incorporated as a calibrated component in commercial ELISA or LC-MS/MS kits for eicosanoid profiling.

Basic Information

Item	Details
Product Name	(+/-)5(6)-Epoxy-8Z,11Z,14Z,17Z-Eicosatetraenoic Acid, Methyl Ester
CAS No.	127716-49-8
Molecular Formula	C21H32O3
Molecular Weight	332.48 g/mol
Synonyms	5(6)-EET Methyl Ester; 5,6-Epoxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid Methyl Ester; Methyl 5,6-Epoxy-8Z,11Z,14Z,17Z-eicosatetraenoate; (±)5(6)-Epoxy-8Z,11Z,14Z,17Z-Eicosatetraenoic Acid Methyl Ester; 5,6-EET-ME; Arachidonic Acid 5,6-Epoxide Methyl Ester; 5(6)-Epoxy-8,11,14,17-eicosatetraenoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) are available upon request, providing detailed results for key parameters such as assay purity and impurity profiles. We adhere to GMP principles in our manufacturing and quality management processes to ensure batch-to-batch consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.