Description

Sivelestat CAS NO 127373-66-4 is a potent and selective inhibitor of neutrophil elastase, a key enzyme implicated in inflammatory tissue damage. This compound is of significant interest for its potential to modulate inflammatory pathways and protect against protease-mediated injury. It is primarily utilized by pharmaceutical researchers and developers in the life sciences sector for drug discovery, preclinical studies, and the investigation of therapeutic interventions for conditions like acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the development of novel anti-inflammatory therapeutics.
• Biochemical Research: Used as a selective tool compound in enzymology studies to investigate the role and mechanism of neutrophil elastase in various disease models.
• Preclinical Studies: Employed in animal models to evaluate efficacy in treating inflammatory conditions such as pancreatitis, ischemia-reperfusion injury, and chronic obstructive pulmonary disease (COPD).
• Inflammatory Disease Mechanism Investigation: Aids in understanding the pathophysiology of diseases where neutrophil infiltration and elastase release are prominent features.
• High-Purity Chemical Reference: Supplied as a high-purity compound for use in analytical method development, validation, and quality control within pharmaceutical manufacturing.

Basic Information

Product Name	Sivelestat
CAS No.	127373-66-4
Molecular Formula	C20H22ClN3O4S
Molecular Weight	435.92 g/mol
Synonyms	ONO-5046; Sivelestat Sodium; Elaspol; Sivelestat Sodium Hydrate; 4-[[[4-[(2,2-Dimethyl-1-oxopropyl)amino]phenyl]sulfonyl]amino]-4-oxobutanoic Acid; N-[4-[(2,2-Dimethylpropanoyl)amino]phenylsulfonyl]glycine, Succinic Acid Monoester; Neutrophil Elastase Inhibitor ONO-5046
EINECS	Contact for details

Quality Control

Our Sivelestat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, identity confirmation by spectroscopic methods, and control of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.