Description

n-(2-[p-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride is a high-purity, synthetic organic compound belonging to the class of isoquinolinesulfonamide derivatives. This compound serves as a critical research-grade biochemical tool, primarily valued for its potent and selective inhibitory activity against specific protein kinases. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on signal transduction pathways, enzyme mechanism studies, and drug discovery programs.

Application

• Biochemical Research: A potent and selective inhibitor for studying protein kinase A (PKA) and other related kinase-dependent cellular processes.
• Pharmaceutical Development: Used as a reference standard and key intermediate in the discovery and synthesis of novel therapeutic agents targeting kinase-related diseases.
• Cell Signaling Studies: Essential tool for elucidating the role of specific kinases in apoptosis, cell proliferation, and differentiation pathways.
• Enzyme Mechanism Analysis: Employed in vitro to determine kinetic parameters and inhibition constants for target enzymes.
• High-Throughput Screening (HTS): Utilized as a control compound in assay development and validation for drug screening platforms.
• Academic Research: Supports fundamental biological and medicinal chemistry research in universities and institutes worldwide.

Basic Information

Product Name	n-(2-[p-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride
CAS No.	127243-85-0
Molecular Formula	C20H21BrN4O2S • HCl
Molecular Weight	497.84 g/mol (Hydrochloride salt)
Synonyms	H-89 Dihydrochloride; N-[2-[[(2E)-3-(4-Bromophenyl)-1-oxo-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide Hydrochloride; 5-Isoquinolinesulfonamide, N-[2-[[(2E)-3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]ethyl]-, hydrochloride (1:1); Protein Kinase A Inhibitor H-89; H-89 (Hydrochloride); PKA Inhibitor H-89 Dihydrochloride; H89 2HCl
EINECS	Contact for details

Quality Control

Our n-(2-[p-Bromocinnamylamino]Ethyl)-5-Isoquinolinesulfonamide Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.