Description

Kn-62 is a potent and selective cell-permeable inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). This compound matters significantly for researchers investigating intracellular calcium signaling pathways, as it provides a critical tool for modulating CaMKII activity with high specificity. Professionals in pharmaceutical R&D, academic biochemistry, and neurobiology laboratories need Kn-62 CAS NO 127191-97-3 for studying roles in neuronal function, cardiac physiology, and related disease mechanisms.

Application

• Biochemical Research: A key pharmacological tool for selectively inhibiting CaMKII activity in in vitro enzyme assays and cell-based studies.
• Neuroscience Studies: Used to investigate the role of CaMKII in synaptic plasticity, long-term potentiation (LTP), memory formation, and neuronal excitability.
• Cardiovascular Research: Applied in studies exploring CaMKII signaling in cardiac myocytes, including its effects on contractility, arrhythmogenesis, and hypertrophy.
• Cellular Signaling Pathway Analysis: Essential for dissecting complex calcium-dependent signaling cascades and their downstream effects in various cell types.
• Drug Discovery & Target Validation: Serves as a reference compound in high-throughput screening and target validation efforts for diseases where CaMKII is implicated.

Basic Information

Product Name	Kn-62
CAS No.	127191-97-3
Molecular Formula	C₂₉H₂₉N₇O₃
Molecular Weight	523.59 g/mol
Synonyms	1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine; KN62; KN-62; CaMKII Inhibitor KN-62; 4-[(2S)-2-[[(5-Isoquinolinylsulfonyl)methylamino]methyl]-1-oxo-3-phenylpropyl]phenyl 5-isoquinolinesulfonate; L-Tyrosine, N-[2-[[(5-isoquinolinylsulfonyl)methylamino]methyl]-1-oxo-3-phenylpropyl]-4-(5-isoquinolinylsulfonyloxy)-, (2S)-; 4-Phenylpiperazine, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-
EINECS	Contact for details

Quality Control

Our Kn-62 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical quality attributes to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.