Description

7-(Deoxyadenosin-N(6)-Yl)Aristolactam I is a structurally defined aristolactam-DNA adduct, a critical reference standard and research chemical in the field of toxicology and carcinogenesis. This compound is essential for studying the metabolic activation and DNA-binding mechanisms of aristolochic acids, which are associated with significant health risks. It is primarily utilized by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on molecular toxicology, biomarker discovery, and the safety assessment of herbal products and environmental contaminants.

Application

• Biomarker Research: Serves as an authentic standard for the detection and quantification of aristolactam-DNA adducts in biological samples, crucial for exposure and risk assessment studies.
• Toxicological Studies: Used in in vitro and in vivo research to investigate the genotoxic and mutagenic pathways of aristolochic acid nephropathy (AAN) and associated urothelial cancers.
• Analytical Method Development: A key calibrant for advanced analytical techniques such as LC-MS/MS, HPLC-fluorescence, and 32P-postlabeling assays to achieve high sensitivity and specificity.
• Mechanistic Biochemistry: Employed to elucidate the enzymatic processes involved in the metabolic activation of aristolochic acids and their subsequent covalent binding to DNA.
• Reference Material Production: Used by certified reference material (CRM) producers to develop and validate quantitative standards for forensic and clinical toxicology laboratories.
• Pharmaceutical Safety Screening: Applied in the safety evaluation pipelines of drug discovery to assess potential DNA-damaging effects of new chemical entities or natural product extracts.

Basic Information

Product Name	7-(Deoxyadenosin-N(6)-Yl)Aristolactam I
CAS No.	127191-86-0
Molecular Formula	C27H25N7O7
Molecular Weight	559.53 g/mol
Synonyms	7-(Deoxyadenosin-N6-yl)aristolactam I; dA-AL-I; N6-(7-Aristolactamyl)-2'-deoxyadenosine; Aristolactam-DNA Adduct I; AL-dA Adduct; 7-(Deoxyadenosin-6-yl)aristolactam I; AA–DNA Adduct I; Deoxyadenosine-aristolactam I adduct
EINECS	Contact for details

Quality Control

Every batch of 7-(Deoxyadenosin-N(6)-Yl)Aristolactam I is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for critical research applications. Our products undergo rigorous quality testing, including comprehensive chromatographic and spectroscopic analyses, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95% (Area Percent)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 3.0% w/w
Specific Storage	Store at -20°C, desiccated, under argon

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.