Description

4-Trifluoromethylbenzylsulfonyl Chloride is a high-value organosulfur building block characterized by its reactive sulfonyl chloride group and trifluoromethyl-substituted aromatic ring. This compound is essential for introducing the 4-(trifluoromethyl)benzylsulfonyl moiety into target molecules, a key step in developing compounds with enhanced metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of sulfonamide-based drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the trifluoromethylbenzylsulfonyl group contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	4-Trifluoromethylbenzylsulfonyl Chloride
CAS No.	127162-96-3
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.64 g/mol
Synonyms	α-Toluenesulfonyl chloride, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)benzylsulfonyl chloride; (4-(Trifluoromethyl)phenyl)methanesulfonyl chloride; 4-(Trifluoromethyl)phenylmethanesulfonyl chloride; 1-(Chlorosulfonylmethyl)-4-(trifluoromethyl)benzene; p-Trifluoromethylbenzylsulfonyl chloride; 4-(Trifluoromethyl)benzylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Trifluoromethylbenzylsulfonyl Chloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for your synthetic processes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications for identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.