Description

Complement Cytolysis Inhibitor CAS NO 127138-17-4 is a specialized biochemical reagent designed to specifically inhibit the complement-mediated cytolysis pathway. This compound is critical for researchers and developers requiring precise control over the complement system in experimental and diagnostic settings. It is primarily utilized in immunology research, in vitro diagnostic (IVD) assay development, and biopharmaceutical process control to study immune responses and ensure product stability.

Application

• Immunological Research: Used as a key tool to study the classical and alternative pathways of complement activation and their role in disease models.
• In Vitro Diagnostic (IVD) Kits: Incorporated into diagnostic assays to control background signal and enhance specificity by inhibiting non-specific complement lysis.
• Biopharmaceutical Development: Employed in cell culture and downstream processing to protect therapeutic cells and proteins from complement-mediated damage.
• Complement System Studies: Essential for investigating disorders like paroxysmal nocturnal hemoglobinuria (PNH) and autoimmune diseases where complement dysregulation is a factor.
• Antibody Characterization: Used in complement-dependent cytotoxicity (CDC) assays to validate the mechanism of action of therapeutic monoclonal antibodies.
• Blood Bank Reagents: A component in reagent formulations used for cross-matching and antibody screening to prevent false-positive hemolysis.

Basic Information

Product Name	Complement Cytolysis Inhibitor
CAS No.	127138-17-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Complement Inhibitor; Cytolysis Inhibitor; Complement Pathway Inhibitor; Terminal Complement Complex Inhibitor; C5b-9 Inhibitor; Membrane Attack Complex (MAC) Inhibitor; CD59 Mimetic; Homologous Restriction Factor 20 (HRF20) related inhibitor
EINECS	Contact for details

Quality Control

Our Complement Cytolysis Inhibitor is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including purity assay and functional activity validation, to ensure consistent performance and reliability for critical research applications. A Certificate of Analysis (COA) detailing identity, purity, potency, and relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The product should be handled in a controlled environment to maintain its integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Biological Activity (Inhibition Assay)	≥ 90% inhibition at specified concentration
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.