Description

3-Oxahomoisocarbacyclin is a synthetic prostaglandin analog, a member of the carbacyclin family. This compound is valued for its potent biological activity as a stable prostacyclin (PGI2) mimetic, offering significant research and development potential. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutics targeting cardiovascular diseases, pulmonary arterial hypertension, and platelet aggregation disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced prostaglandin-based drugs.
• Cardiovascular Research: Used as a reference standard and active agent in studies of vasodilation, platelet inhibition, and ischemia-reperfusion injury.
• Pulmonary Research: Investigated for its potential effects in models of pulmonary hypertension and related vascular disorders.
• Cell Signaling Studies: Employed to study IP receptor (prostacyclin receptor) activation and downstream cyclic AMP pathways.
• Fine Chemical Synthesis: Serves as a sophisticated chiral template for the preparation of other bioactive molecules.

Basic Information

Product Name	3-Oxahomoisocarbacyclin
CAS No.	127127-92-8
Molecular Formula	C₂₂H₃₄O₅
Molecular Weight	378.50 g/mol
Synonyms	9(0)-Methano-δ⁶(9α)-PGI₁; 3-Oxa-17,18,19,20-tetranor-16-carbaprostaglandin I₂; 3-Oxahomo-isocarbacyclin; Carbacyclin analog; 3-Oxa-carbacyclin derivative; Stable prostacyclin analog; 15-Cyclopentyl-ω-pentanor-3-oxaprostan-1-oic acid derivative
EINECS	Contact for details

Quality Control

Our 3-Oxahomoisocarbacyclin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and batch-to-batch consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.