Description

(5Z,7E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19)-Trien-24-One is a high-purity, synthetic vitamin D analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis of novel secosteroids and for probing vitamin D receptor (VDR) signaling pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic bone disease research, oncology, and the development of new therapeutic agents targeting nuclear hormone receptors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel vitamin D analogs and secosteroid derivatives with potential therapeutic applications.
• Biochemical Research: Used as a reference standard or probe in studies investigating vitamin D metabolism, receptor binding affinity, and genomic/non-genomic signaling mechanisms.
• Drug Discovery & Development: Serves as a precursor in medicinal chemistry programs aimed at creating new treatments for osteoporosis, psoriasis, cancer, and autoimmune disorders.
• Analytical Standard: High-purity material for use as an external standard in HPLC, LC-MS, and NMR methods for quality control and metabolic studies.
• Academic Research: Employed in university and institutional labs for fundamental studies in steroid chemistry and endocrinology.

Basic Information

Product Name	(5Z,7E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19)-Trien-24-One
CAS No.	126860-84-2
Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.61 g/mol
Synonyms	26,27-Cyclo-1α,3β-dihydroxyvitamin D₃; 26,27-Cyclo-1α,3β-dihydroxycholecalciferol; 1α,3β-Dihydroxy-26,27-cyclovitamin D₃; 26,27-Cyclo-1α,3β-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-24-one; Cyclovitamin D₃ analog; Secosteroid intermediate; Vitamin D₃ analog (26,27-cyclo)
EINECS	Contact for details

Quality Control

Our (5Z,7E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19)-Trien-24-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.