Description

(5Z,7E,22E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19),22-Tetren-24-One is a high-purity, synthetic vitamin D analog and secosteroid derivative, identified by CAS No. 126860-83-1. This compound is critical for advanced pharmaceutical research and development, particularly in the study of vitamin D receptor (VDR) signaling pathways and metabolic bone disorders. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the synthesis of novel therapeutics and reference standards.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and probe in studies of vitamin D metabolism, calcium homeostasis, and VDR-mediated gene expression.
• Drug Discovery: Serves as a core scaffold for developing new therapeutic agents targeting osteoporosis, psoriasis, and certain cancers.
• Analytical Standard: Provides a high-purity standard for quality control and method validation in HPLC, LC-MS, and other analytical techniques.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical products.

Basic Information

Product Name	(5Z,7E,22E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19),22-Tetren-24-One
CAS No.	126860-83-1
Molecular Formula	C₂₇H₃₈O₃
Molecular Weight	410.59 g/mol
Synonyms	26,27-Cyclo-1α,3β-dihydroxy-22,23-didehydrovitamin D₃; 1α,3β-Dihydroxy-26,27-cyclo-22-dehydrovitamin D₃; 26,27-Cyclo-22-dehydro-1α,25-dihydroxyvitamin D₃ analog; (5Z,7E,22E)-1α,3β-Dihydroxy-9,10-secocholesta-5,7,10(19),22-tetraen-26,27-cyclo-24-one; Vitamin D3 derivative, 26,27-cyclo-22-dehydro-1α,3β-diol; 126860-83-1; 1α,3β-Dihydroxy-26,27-cyclovitamin D₃ 22-ene
EINECS	Contact for details

Quality Control

Our (5Z,7E,22E)-9,10-Seco-26,27-Cyclo-1α,3β-Dihydroxycholesta-5,7,10(19),22-Tetren-24-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with research-grade and potential cGMP standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere if specified and handled in a controlled environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.