Description

Abx (Antibody Exchanger) is a specialized functionalized polymer designed for the purification and analysis of monoclonal antibodies and other biologics. Its core value lies in enabling high-resolution separation and efficient capture of target biomolecules, which is critical for downstream processing in biopharmaceutical manufacturing. This product is essential for research institutions, diagnostic kit manufacturers, and biopharmaceutical companies engaged in antibody development, quality control, and large-scale production.

Application

• Monoclonal Antibody (mAb) Purification: Used as a key chromatographic medium for the capture and intermediate purification of IgG and other antibody subclasses from complex cell culture harvests.
• Affinity Chromatography: Serves as a robust ligand support for the specific isolation of antibodies based on antigen-binding or Fc-region interactions.
• Analytical Sample Preparation: Employed in spin columns or microplate formats for rapid antibody extraction and clean-up prior to HPLC, MS, or ELISA analysis.
• Diagnostic Reagent Manufacturing: Integral in the production and purification of antibody conjugates (e.g., enzyme-labeled, fluorescent) used in immunoassays and lateral flow tests.
• Process Development & Scale-Up: Provides a scalable platform for optimizing purification conditions from laboratory bench to pilot and commercial manufacturing scales.
• Antibody Fragment Isolation: Effective for purifying Fab, F(ab')2, and scFv fragments generated via enzymatic digestion or recombinant expression.

Basic Information

Product Name	Abx (Antibody Exchanger)
CAS No.	126850-08-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Antibody Exchange Resin; Protein A Mimetic Ligand; Affinity Chromatography Medium for Antibodies; Immunoaffinity Sorbent; Mab Selector; Polymeric Antibody Binder; Immunoglobulin Binding Polymer; (alternate trade names may apply)
EINECS	Contact for details

Quality Control

Every batch of Abx (Antibody Exchanger) is manufactured under a quality management system and undergoes rigorous testing to ensure performance consistency and lot-to-lot reproducibility. Key parameters such as ligand density, binding capacity, and particle size distribution are strictly controlled. A comprehensive Certificate of Analysis (COA) documenting purity, performance specifications, and absence of significant leachables is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake, which can affect performance. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white beads
Particle Size	Contact for details
Binding Capacity (Human IgG)	> 30 mg/mL resin
Ligand Density	Contact for details
Matrix	Highly cross-linked polymeric base
Storage Solution	20% Ethanol
pH Stability (working range)	3 - 10
Pressure Stability	> 5 bar

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.