Description

Nagstatin is a potent and specific inhibitor of N-acetyl-β-D-glucosaminidase (NAGase), an enzyme with significant biological relevance. This high-purity compound is essential for researchers and manufacturers requiring precise enzymatic control in biochemical studies and diagnostic applications. It is particularly valuable for the pharmaceutical, biotechnology, and in-vitro diagnostic (IVD) reagent industries, where it is used to study lysosomal storage disorders, develop enzyme assays, and create diagnostic kits.

Application

• Biochemical Research: A critical tool for studying the activity and function of N-acetyl-β-D-glucosaminidase in metabolic pathways and disease models.
• Diagnostic Reagent Manufacturing: Used as a key component in the formulation of IVD kits for the detection and quantification of NAGase activity in clinical samples.
• Pharmaceutical Development: Serves as a reference standard and inhibitor in drug discovery programs targeting lysosomal enzymes and related disorders.
• Enzyme Assay Development: Employed to establish specific and sensitive assay conditions for NAGase, aiding in high-throughput screening and quality control.
• Academic & Clinical Laboratories: Utilized for investigative studies into conditions like Tay-Sachs disease, where NAGase activity is a marker.

Basic Information

Product Name	Nagstatin
CAS No.	126844-81-3
Molecular Formula	C₁₇H₂₈N₂O₈
Molecular Weight	388.42 g/mol
Synonyms	PUGNAc; O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate; NAGstatin; N-Acetylglucosaminidase Inhibitor; NAGase Inhibitor; 2-Acetamido-1,2-dideoxynojirimycin derivative; Phenylcarbamoyl-2-acetamido-2-deoxy-D-glucopyranosylamine
EINECS	Contact for details

Quality Control

Our Nagstatin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for fine chemical manufacturing to support our customers' quality requirements in pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Biological Activity (IC₅₀)	Reported per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.