Description

5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyridine is a high-value halogenated pyridine derivative, distinguished by its bromine and trifluoroethoxy substituents. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, particularly in the development of active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Essential for methodological studies in cross-coupling reactions and fluorinated compound chemistry.

Basic Information

Product Name	5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyridine
CAS No.	126728-58-3
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)-5-bromopyridine; 5-Bromo-2-(2,2,2-trifluoroethoxy)pyridine; 5-Bromo-2-(trifluoroethoxy)pyridine; Pyridine, 5-bromo-2-(2,2,2-trifluoroethoxy)-; 126728-58-3; 5-Bromo-2-(2,2,2-trifluoroethyloxy)pyridine
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-(2,2,2-trifluoro-ethoxy)-pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Melting Point	Contact for details
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.