Description

n-Hydroxythalidomide is a key synthetic intermediate and derivative of thalidomide, primarily used in advanced pharmaceutical research and development. This compound is of significant interest for its role in the study of immunomodulatory and anti-inflammatory agents, as well as in the development of targeted protein degradation (PROTAC) technologies. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on novel therapeutic discovery and chemical biology.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel thalidomide analogs and derivatives for drug discovery programs.
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a ligand component for E3 ubiquitin ligase in the design of bifunctional molecules for targeted protein degradation.
• Immunomodulatory Research: Used in preclinical studies to investigate mechanisms of action related to TNF-α inhibition and T-cell co-stimulation.
• Chemical Biology Probe: Employed as a tool compound to study cereblon (CRBN) binding and its downstream effects in cellular models.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Academic Research: Fundamental research in medicinal chemistry and pharmacology for understanding structure-activity relationships (SAR).

Basic Information

Product Name	n-Hydroxythalidomide
CAS No.	126663-38-5
Molecular Formula	C13H10N2O5
Molecular Weight	274.23 g/mol
Synonyms	1-Hydroxythalidomide; N-Hydroxythalidomide; 2-(2,6-Dioxopiperidin-3-yl)-1-hydroxyisoindoline-1,3-dione; 1-Hydroxy-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; Thalidomide N-oxide derivative; Hydroxylated thalidomide analog; CRBN ligand precursor
EINECS	Contact for details

Quality Control

Our n-Hydroxythalidomide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not intended for human therapeutic use, production adheres to principles of current Good Manufacturing Practice (cGMP) where applicable for non-GMP materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.