Description

Cyclophellitol CAS NO 126661-83-4 is a potent and selective mechanism-based inhibitor of retaining β-glucosidases. This compound is a highly valuable biochemical tool for the study of glycosidase enzymes and carbohydrate metabolism. It is primarily utilized by researchers in pharmaceutical development, enzymology, and chemical biology for probing enzyme mechanisms and developing therapeutic strategies for lysosomal storage disorders and other related diseases.

Application

• Enzyme Mechanism Studies: As an active-site directed, irreversible inhibitor for detailed kinetic and structural analysis of β-glucosidases.
• Chemical Biology Probes: Serves as a core structure for developing activity-based probes (ABPs) to visualize and profile glycosidase activity in complex biological systems.
• Pharmaceutical Research: Used in target validation and drug discovery programs for diseases involving glycosidase dysfunction, such as Gaucher disease.
• Biochemical Assay Development: Employed as a reference standard and positive control in high-throughput screening assays for glycosidase inhibitors.
• Glycobiology Research: A critical tool for investigating carbohydrate processing, lysosomal function, and metabolic pathways in cell culture and model organisms.

Basic Information

Product Name	Cyclophellitol
CAS No.	126661-83-4
Molecular Formula	C7H12O5
Molecular Weight	176.17 g/mol
Synonyms	(1S,2R,3S,4R,6S)-4,6-Dihydroxy-3-(hydroxymethyl)cyclohex-4-ene-1,2-diol; 1,2-Anhydro-myo-inositol; Conduritol B epoxide analog; β-Glucosidase inhibitor; 1,6-Anhydro-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohex-4-ene
EINECS	Contact for details

Quality Control

Our Cyclophellitol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and specific optical rotation measurement. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.