Description

4'-Demethylamino-4'-Hydroxystaurosporine is a chemically modified derivative of the potent protein kinase inhibitor staurosporine, offering distinct biochemical properties. This compound is a critical research-grade intermediate and reference standard for investigating cellular signaling pathways and kinase inhibition mechanisms. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and neurodegenerative disease research.

Application

• Biochemical Research: As a key reference standard and tool compound for studying protein kinase C (PKC) and other serine/threonine kinases in vitro.
• Pharmaceutical Development: Serves as a crucial intermediate in the synthesis and structure-activity relationship (SAR) studies of novel kinase inhibitor candidates.
• Cell Biology Studies: Used to induce apoptosis and study cell cycle arrest mechanisms in various cancer cell lines.
• Signal Transduction Research: A valuable probe for dissecting complex intracellular signaling cascades involved in proliferation and differentiation.
• Neuroscience Research: Investigated for its potential effects on neuronal survival and its role in models of neurodegenerative conditions.

Basic Information

Product Name	4'-Demethylamino-4'-Hydroxystaurosporine
CAS No.	126572-73-4
Molecular Formula	C27H24N4O4
Molecular Weight	468.50 g/mol
Synonyms	4'-Demethylamino-4'-hydroxystaurosporine; 4'-Demethylamino-4'-hydroxy-staurosporine; 4'-Demethylamino-4'-OH-staurosporine; 4'-NH2-4'-OH-Staurosporine; 4'-Amino-4'-hydroxystaurosporine (common name); Staurosporine derivative, 4'-demethylamino-4'-hydroxy-; 4'-Demethylamino-4'-hydroxy K-252a derivative
EINECS	Contact for details

Quality Control

Our 4'-Demethylamino-4'-Hydroxystaurosporine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.