Description

Eponemycin is a potent and specific proteasome inhibitor of significant interest in biochemical and pharmacological research. This compound matters for its ability to selectively target the 20S proteasome, making it a critical tool for studying protein degradation pathways, cellular apoptosis, and mechanisms of cancer. Researchers in the fields of oncology, neurobiology, and immunology need it to investigate disease mechanisms and develop novel therapeutic strategies. Its unique biological activity underpins its value in high-value discovery and development programs.

Application

• Biochemical Research: A fundamental tool for studying the structure, function, and inhibition kinetics of the 20S proteasome complex in vitro.
• Cancer Biology Studies: Used to investigate the role of proteasome-mediated protein degradation in tumor cell proliferation, survival, and apoptosis.
• Mechanism of Action (MoA) Research: Employed as a reference standard to validate the proteasome-inhibitory activity of novel drug candidates and natural products.
• Neurodegenerative Disease Models: Applied in research models to explore the link between proteasome dysfunction and pathologies like Alzheimer's and Parkinson's disease.
• Immunology Research: Utilized to study antigen processing and presentation pathways mediated by the immunoproteasome.
• Cell Signaling Pathway Analysis: A key reagent for dissecting ubiquitin-proteasome system-dependent signaling cascades.

Basic Information

Product Name	Eponemycin
CAS No.	126509-46-4
Molecular Formula	C34H47NO8
Molecular Weight	597.75 g/mol
Synonyms	Epoxomicin; (2S,3R)-N-((2S,3R)-2-Hydroxy-3-methyl-1-oxopentan-3-yl)-3-(((2S)-1-((2S)-2-((2R)-2-methyloxiran-2-yl)-2-oxoethyl)-4-methyl-1-oxopentan-2-yl)amino)-2-methyl-5-phenylpentanamide; BU-4514N; Proteasome Inhibitor I; Clasto-Lactacystin β-lactone analog
EINECS	Contact for details

Quality Control

Our Eponemycin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.