Description

Dihydroeponemycin is a potent and selective proteasome inhibitor derived from the natural product epoxomicin. This compound is a critical research tool for studying cellular protein degradation pathways, apoptosis, and the role of the proteasome in various disease states. It is primarily utilized by researchers and scientists in the fields of oncology, neurobiology, and immunology for biochemical and pharmacological investigations. Dihydroeponemycin CAS NO 126463-64-7 offers high biological activity for probing proteasome function in vitro and in vivo.

Application

• Biochemical Research: A key reagent for studying the mechanism and inhibition kinetics of the 20S proteasome complex.
• Cancer Research: Used to investigate the induction of apoptosis in various cancer cell lines and to validate the proteasome as a therapeutic target.
• Neurodegenerative Disease Studies: Employed in models of diseases like Alzheimer's and Parkinson's to understand the role of protein aggregation and clearance.
• Immunology Research: Applied to study antigen presentation and the modulation of NF-κB signaling pathways.
• Pharmacology & Drug Discovery: Serves as a reference standard and a lead compound for developing novel proteasome inhibitors.
• Cell Biology: Utilized to analyze the effects of proteasomal blockade on cell cycle progression and protein turnover.

Basic Information

Product Name	Dihydroeponemycin
CAS No.	126463-64-7
Molecular Formula	C28H41N3O7
Molecular Weight	531.65 g/mol
Synonyms	Dihydro-Eponemycin; (2S,3R)-N-((2S,3R)-3-Hydroxy-1-(((2S,3R,4S,5S)-5-((S)-2-Hydroxy-2-methyl-3-(methylamino)-3-oxopropyl)-3,4-dimethyltetrahydrofuran-2-yl)amino)-1-oxobutan-2-yl)-3-hydroxy-2-((2S,3S)-3-((S)-2-methyloxiran-2-yl)butanamido)butanamide; Epoxomicin derivative; Proteasome Inhibitor II (Dihydroeponemycin)
EINECS	Contact for details

Quality Control

Our Dihydroeponemycin is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (Karl Fischer)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.