Description

5'-Iodoindirubin (CAS NO 126433-42-9) is a halogenated derivative of the natural product indirubin, a compound of significant interest in medicinal chemistry and biochemical research. This modification enhances its biological activity and selectivity, making it a valuable tool compound for studying cellular signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Kinase Inhibition Research: Serves as a potent and selective chemical probe for studying specific kinase targets in signal transduction pathways.
• Anti-cancer Drug Discovery: Investigated as a lead compound or intermediate for the development of novel anti-proliferative and chemotherapeutic agents.
• Biochemical Assay Development: Used as a reference standard or active component in high-throughput screening (HTS) assays and in vitro studies.
• Cell Cycle Regulation Studies: Applied in academic and industrial research to elucidate mechanisms of cell cycle control and apoptosis.
• Pharmaceutical Intermediate: Functions as a key synthetic building block for the preparation of more complex indirubin-based drug candidates.
• Target Validation: Employed to validate the role of specific molecular targets in disease models, aiding in preclinical research.

Basic Information

Product Name	5'-Iodoindirubin
CAS No.	126433-42-9
Molecular Formula	C16H9IN2O2
Molecular Weight	412.16 g/mol
Synonyms	5'-Iodoindirubin; 5-Iodoindirubin; 1H-Indole-2,3-dione, 5-iodo-3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-2,3-dihydro-; (E)-5-Iodo-3-(3-oxo-1,3-dihydro-2H-indol-2-ylidene)indolin-2-one; 5-Iodo-3-(3-oxo-1,3-dihydro-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; Indirubin, 5'-iodo-
EINECS	Contact for details

Quality Control

Our 5'-Iodoindirubin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Red to brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.