Description

Tyrphostin A51 CAS NO 126433-07-6 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for biochemical and pharmacological studies.

Application

• Biochemical Research: A key tool for investigating EGFR-mediated signaling cascades and their role in cellular processes.
• Oncology Research: Used in vitro and in vivo studies to explore the therapeutic potential of EGFR inhibition in various cancer models.
• Signal Transduction Studies: Employed to dissect and validate specific pathways in cell biology and molecular pharmacology.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the screening and development of novel tyrosine kinase inhibitors.
• Academic Research: Fundamental research in universities and institutes for understanding receptor tyrosine kinase function.

Basic Information

Product Name	Tyrphostin A51
CAS No.	126433-07-6
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 555; Tyrphostin AG 555; RG 50810; 2,5-Dihydroxybenzylidene Malononitrile; 2-[(2,5-Dihydroxyphenyl)methylene]propanedinitrile; 4-Hydroxy-3-(2,5-dihydroxybenzylidene)-2-butenenitrile; EGFR Tyrosine Kinase Inhibitor AG 555
EINECS	Contact for details

Quality Control

Our Tyrphostin A51 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.