Description

Desacetylnavelbine is a key pharmaceutical intermediate and a structural analog of the potent anticancer agent vinorelbine. This compound is of critical importance in the research and development of novel chemotherapeutic agents, particularly for the treatment of various cancers. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for synthesis and process optimization studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of vinorelbine and related vinca alkaloid derivatives.
• Anticancer Research: Used as a reference standard and starting material in preclinical studies to investigate structure-activity relationships and develop new oncology drugs.
• Process Chemistry: Employed in the development and scaling up of manufacturing processes for complex pharmaceutical compounds.
• Analytical Standard: Serves as a high-purity standard for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical laboratories.
• Biochemical Research: Used in studies exploring mechanisms of action involving tubulin binding and mitosis inhibition.

Basic Information

Product Name	Desacetylnavelbine
CAS No.	126347-74-8
Molecular Formula	C44H54N4O7
Molecular Weight	750.93 g/mol
Synonyms	Desacetyl Vinorelbine; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine; 5'-Noranhydrovinblastine; Deacetyl Vinorelbine; 4-Deacetylvinorelbine; 20'-Deoxy-3',4'-didehydro-4'-deoxy-8'-norvincaleukoblastine; Navelbine Impurity C; Vinorelbine Related Compound C
EINECS	Contact for details

Quality Control

Our Desacetylnavelbine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles as determined by advanced chromatographic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.