Description

7-Ethyl-10-Methoxy-20-Deoxyaminocamptothecin is a synthetic derivative of the potent topoisomerase I inhibitor, camptothecin, designed to enhance stability and therapeutic potential. This compound is of significant interest for its role as a key intermediate or active pharmaceutical ingredient (API) in advanced oncology research and development. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and academic laboratories focused on developing novel chemotherapeutic agents and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation camptothecin-based anticancer drugs.
• Oncology Research: Used as a reference standard or active compound in in vitro and in vivo studies to investigate mechanisms of topoisomerase I inhibition and apoptosis.
• Drug Discovery & Development: A vital component in high-throughput screening and structure-activity relationship (SAR) studies to optimize antitumor efficacy and reduce toxicity.
• API Manufacturing: Employed in the controlled production of finished dosage forms for clinical trial materials under Good Manufacturing Practice (GMP) guidelines.
• Biochemical Research: Utilized in enzymatic assays to study DNA replication, repair, and the interaction between topoisomerase I and DNA.

Basic Information

Product Name	7-Ethyl-10-Methoxy-20-Deoxyaminocamptothecin
CAS No.	126266-02-2
Molecular Formula	C23H23N3O5
Molecular Weight	421.45 g/mol
Synonyms	20-Deoxy-7-ethyl-10-methoxycamptothecin; 7-Ethyl-10-methoxy-20-deoxycamptothecin; 20-Deoxyaminocamptothecin; DB-67 (Drug Bank ID); (S)-7-Ethyl-10-methoxy-20-deoxycamptothecin; Camptothecin derivative 7-ethyl-10-methoxy-20-deoxy; 20-Desoxy-7-ethyl-10-methoxycamptothecin
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Methoxy-20-Deoxyaminocamptothecin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development projects requiring material compliant with ICH guidelines and can supply custom grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive (store away from light). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.