Description

7-Ethyl-10-Hydroxy-20-Deoxyaminocamptothecin is a synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is of significant interest for its potential as a key intermediate or active pharmaceutical ingredient (API) in advanced oncology research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on developing novel chemotherapeutic agents and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation camptothecin-based anticancer drugs.
• Oncology Research: Used as a reference standard or active compound in biochemical and cellular assays to study topoisomerase I inhibition mechanisms.
• Drug Discovery & Development: Employed in preclinical studies to evaluate the efficacy, pharmacokinetics, and structure-activity relationships (SAR) of novel antitumor agents.
• API Manufacturing: Acts as a precursor in the controlled, multi-step synthesis of complex therapeutic molecules for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research on DNA replication, cell cycle arrest, and apoptosis induction.

Basic Information

Product Name	7-Ethyl-10-Hydroxy-20-Deoxyaminocamptothecin
CAS No.	126266-01-1
Molecular Formula	C22H23N3O4
Molecular Weight	393.44 g/mol
Synonyms	7-Ethyl-10-hydroxy-20-deoxyaminocamptothecin; 20-Deoxyaminocamptothecin derivative; SN-38 Deoxyamino analog; 7-Ethyl-10-hydroxycamptothecin 20-deoxyamino derivative; (S)-7-Ethyl-10-hydroxy-20-deoxyaminocamptothecin; Camptothecin, 7-ethyl-10-hydroxy-20-deoxyamino-; Potential research code: DX-8951 related compound
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Hydroxy-20-Deoxyaminocamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.