Description

Iodotyrosyl-Prolyl-Arginyl Chloromethyl Ketone is a synthetic peptide chloromethyl ketone derivative, a potent and irreversible inhibitor designed for targeted protease research. This compound matters for its high specificity in biochemical studies, enabling precise investigation of enzyme mechanisms and pathways. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, proteomics, and the development of diagnostic assays.

Application

• Protease Inhibition Studies: Acts as a specific, irreversible active-site inhibitor for studying serine and cysteine protease kinetics and function.
• Biochemical Research Reagent: Used in academic and industrial laboratories to elucidate enzymatic pathways and protein-protein interactions.
• Pharmaceutical Development: Serves as a key intermediate or tool compound in the discovery and optimization of novel therapeutic agents targeting proteolytic enzymes.
• Proteomics & Diagnostic Assay Development: Employed in the design and validation of assays for detecting and quantifying specific protease activity in biological samples.

Basic Information

Product Name	Iodotyrosyl-Prolyl-Arginyl Chloromethyl Ketone
CAS No.	126251-21-6
Molecular Formula	C23H33ClIN7O5
Molecular Weight	649.91 g/mol
Synonyms	Iodo-Tyr-Pro-Arg-CH2Cl; IYPR-CH2Cl; TPCK Analogue; Iodotyrosyl-prolyl-arginyl chloromethane; Protease Inhibitor 126251-21-6; Chloromethyl Ketone Inhibitor IYPR; N-α-Tosyl-L-phenylalanine chloromethyl ketone analogue; L-Iodotyrosyl-L-prolyl-L-arginyl chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Iodotyrosyl-Prolyl-Arginyl Chloromethyl Ketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.