Description

Npf-Etoposide CAS NO 125830-36-6 is a high-purity pharmaceutical intermediate and reference standard, specifically a derivative of the potent antineoplastic agent etoposide. This compound is critical for research and development in oncology, serving as a key building block in the synthesis of novel chemotherapeutic agents and for analytical method development. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cancer drug discovery and quality control processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of etoposide and related podophyllotoxin derivatives for anticancer formulations.
• Reference Standard: Used in analytical laboratories for the identification, assay, and impurity profiling of etoposide in Active Pharmaceutical Ingredient (API) and finished drug products via HPLC, LC-MS, or NMR.
• Research & Development: Employed in biochemical and pharmacological studies to investigate structure-activity relationships (SAR), mechanism of action, and metabolic pathways of topoisomerase II inhibitors.
• Process Development: Utilized in scaling up and optimizing synthetic routes for etoposide production under current Good Manufacturing Practices (cGMP).
• Impurity Standard: Acts as a specified impurity or degradation product standard for stability testing and regulatory filing (e.g., ICH guidelines) of etoposide-based drugs.

Basic Information

Product Name	Npf-Etoposide
CAS No.	125830-36-6
Molecular Formula	C29H32O13
Molecular Weight	588.56 g/mol
Synonyms	4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-Ethylidene-β-D-glucopyranoside], 4'-Desmethylepipodophyllotoxin benzylidene glucoside; Etoposide impurity; Etoposide derivative; Podophyllotoxin derivative; VP-16-213 derivative; (5R,5aR,8aR,9S)-9-(((2R,3R,4S,5S,6R)-4-Ethoxy-5-hydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
EINECS	Contact for details

Quality Control

Our Npf-Etoposide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, identification by spectroscopic methods (IR, NMR), and control of specified impurities. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment. We support compliance with relevant pharmacopeial standards and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.