Description

Saclofen CAS NO 125464-42-8 is a potent and selective competitive antagonist for GABAB receptors, serving as a crucial pharmacological tool in neuroscience research. Its primary value lies in its ability to selectively block GABAB receptor-mediated responses, enabling the study of inhibitory neurotransmission and related neurological pathways. This compound is essential for researchers and pharmaceutical developers in the fields of neuropharmacology, neurophysiology, and central nervous system (CNS) drug discovery.

Application

• Neuroscience Research: A fundamental tool for investigating the role of GABAB receptors in synaptic transmission, neuronal excitability, and network oscillations.
• Pharmacological Studies: Used in in vitro and ex vivo assays to characterize receptor function, ligand binding, and signal transduction mechanisms of GABAB receptors.
• Drug Discovery & Development: Serves as a reference standard and screening agent in the development of novel therapeutics targeting neurological and psychiatric disorders such as epilepsy, spasticity, anxiety, and addiction.
• Academic & Institutional Research: Employed in university and government laboratories for basic science research into the GABAergic system and its implications for brain function and disease.

Basic Information

Product Name	Saclofen
CAS No.	125464-42-8
Molecular Formula	C9H14ClNO4S
Molecular Weight	267.73 g/mol
Synonyms	3-Amino-2-(4-chlorophenyl)propylsulfonic acid; (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid; (±)-Saclofen; β-(4-Chlorophenyl)-γ-aminopropylsulfonic acid; GABAB receptor antagonist saclofen; (R,S)-Saclofen; 2-Hydroxy-3-[2-[(4-chlorophenyl)methyl]amino]ethyl]sulfonyl]propanoic acid (related form)
EINECS	Contact for details

Quality Control

Our Saclofen is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.