Description

Ro 31-8220 Methanesulfonate is a potent, cell-permeable, and selective protein kinase C (PKC) inhibitor with significant research utility. This compound is valued for its high specificity and efficacy in modulating PKC activity within cellular signaling pathways. It is primarily needed by researchers and scientists in the fields of biochemistry, cell biology, and pharmacology for investigating signal transduction mechanisms, cancer biology, and neurological disorders.

Application

• Biochemical Research: A critical tool for studying the role of Protein Kinase C (PKC) isoforms in intracellular signaling cascades.
• Cell Biology Studies: Used to inhibit PKC activity in cell culture models to elucidate its function in processes like proliferation, differentiation, and apoptosis.
• Pharmacology & Drug Discovery: Serves as a reference standard and pharmacological probe in the development of novel kinase-targeted therapeutics.
• Neuroscience Research: Applied in studies exploring PKC's involvement in neurotransmitter release, synaptic plasticity, and neurodegenerative conditions.
• Oncology Research: Utilized to investigate the contribution of PKC signaling to tumor progression, metastasis, and resistance to chemotherapy.
• Inflammation & Immunology: Employed to dissect PKC-mediated pathways in immune cell activation and inflammatory responses.

Basic Information

Product Name	Ro 31-8220 Methanesulfonate
CAS No.	125314-64-9
Molecular Formula	C26H27N5O4S
Molecular Weight	505.59 g/mol
Synonyms	Ro 31-8220; Ro-31-8220; Ro318220; 3-[1-[3-(Amidinothio)propyl]-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; Protein Kinase C Inhibitor Ro 31-8220; 3-[1-[3-(Amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
EINECS	Contact for details

Quality Control

Our Ro 31-8220 Methanesulfonate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for critical research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (Karl Fischer)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.