Description

1-(Deoxyguanosin-N(2)-Yl)-2-Aminophenanthrene is a structurally defined, high-purity chemical reference standard. This compound is of significant value in biochemical and toxicological research, particularly for studying DNA adduct formation and mutagenesis. It serves as a critical analytical standard for laboratories in the pharmaceutical, biotechnology, and environmental safety sectors requiring precise quantification of DNA damage.

Application

• Biomarker Research: Used as a reference standard for the detection and quantification of specific DNA adducts in biological samples.
• Toxicology Studies: Essential for investigating the mechanisms of chemical carcinogenesis and mutagenicity related to polycyclic aromatic compounds.
• Analytical Method Development: Serves as a critical calibrant in HPLC, LC-MS, and other chromatographic/spectrometric methods for DNA damage analysis.
• Pharmaceutical Safety Assessment: Employed in preclinical studies to understand potential genotoxic effects of drug candidates.
• Environmental Monitoring: Aids in assessing human exposure to environmental pollutants by serving as a model adduct for analytical comparisons.
• Academic Research: Used in universities and research institutes for fundamental studies on DNA repair mechanisms and chemical biology.

Basic Information

Product Name	1-(Deoxyguanosin-N(2)-Yl)-2-Aminophenanthrene
CAS No.	125310-67-0
Molecular Formula	C27H25N7O4
Molecular Weight	511.53 g/mol
Synonyms	1-(2'-Deoxyguanosin-N²-yl)-2-aminophenanthrene; N-(Deoxyguanosin-8-yl)-2-aminophenanthrene; dG-N²-2-AP; 2-Aminophenanthrene-deoxyguanosine adduct; DNA Adduct Standard (2-AP-dG); 1-(N²-Deoxyguanosyl)-2-aminophenanthrene; Phenanthren-2-amine, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-on-2-yl)-
EINECS	Contact for details

Quality Control

This high-purity biochemical standard is manufactured under strict quality control protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and chromatographic data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.