Description

Fatostatin A CAS NO 125256-00-0 is a potent and selective small-molecule inhibitor of sterol regulatory element-binding protein (SREBP) activation. This compound matters as a critical research tool for studying lipid metabolism, adipogenesis, and related metabolic disorders. It is needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disease, cancer metabolism, and drug discovery programs.

Application

• Biomedical Research: Used as a key pharmacological agent to inhibit SREBP processing and study its role in cholesterol and fatty acid biosynthesis pathways.
• Metabolic Disease Studies: Applied in cellular and animal models to investigate conditions like obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD).
• Cancer Research: Utilized to explore the dependency of certain cancer cells on de novo lipogenesis for proliferation and survival.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput screens for novel lipid metabolism modulators.
• Academic & Institutional Labs: Fundamental research tool for dissecting the transcriptional regulation of lipid homeostasis.
• Preclinical Development: Supports proof-of-concept studies for therapeutic candidates targeting the SREBP pathway.

Basic Information

Product Name	Fatostatin A
CAS No.	125256-00-0
Molecular Formula	C₂₉H₄₀O₄
Molecular Weight	452.63 g/mol
Synonyms	Fatostatin; Fatostatin A Hydrobromide (salt form); BZP; SREBP Inhibitor; NSC 281033; 4-Methyl-N-[9-methyl-3-(1-naphthalenyl)-1H-pyrazolo[3,4-b]quinolin-1-yl]benzenesulfonamide; 1H-Pyrazolo[3,4-b]quinoline, 9-methyl-3-(1-naphthalenyl)-1-[[(4-methylphenyl)sulfonyl]amino]-
EINECS	Contact for details

Quality Control

Our Fatostatin A is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure high batch-to-batch consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is light-sensitive; handling should be performed under subdued light where practical. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.