Description

Syringostatin A CAS NO 125051-66-3 is a potent and specific proteasome inhibitor of significant interest in biochemical and pharmaceutical research. This compound matters for its ability to selectively inhibit the chymotrypsin-like activity of the 20S proteasome, a key regulator of intracellular protein degradation. Researchers in oncology, neurobiology, and immunology require it to study disease mechanisms and explore novel therapeutic pathways. Its high specificity makes it a valuable tool for dissecting proteasome function in complex biological systems.

Application

• Biochemical Research: Used as a specific molecular probe to study the structure, function, and inhibition mechanisms of the 20S proteasome complex.
• Oncology Research: Employed in in vitro and in vivo studies to investigate the role of proteasome inhibition in cancer cell apoptosis and tumor progression.
• Neurodegenerative Disease Studies: Applied in research models for Alzheimer's, Parkinson's, and other diseases to understand protein aggregation and clearance pathways.
• Immunology Research: Utilized to explore the modulation of NF-κB signaling and cytokine production, which are regulated by proteasome activity.
• Drug Discovery & Development: Serves as a reference compound or lead structure for the development of novel proteasome-targeting therapeutics.
• Cell Biology Assays: Acts as a critical reagent in assays designed to measure proteasome activity and protein turnover rates within cells.

Basic Information

Item	Detail
Product Name	Syringostatin A
CAS No.	125051-66-3
Molecular Formula	C₃₄H₅₇N₅O₇
Molecular Weight	647.85 g/mol
Synonyms	Syringostatin A; Syringostatin; Proteasome Inhibitor Syringostatin A; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(2S)-Butan-2-yl]-33-[(2R)-1-hydroxybutan-2-yl]-6,9,18,21,24-pentaisopropyl-3,12,15-trimethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-1λ⁵,4λ⁵,7λ⁵,10λ⁵,13λ⁵,16λ⁵,19λ⁵,22λ⁵,25λ⁵,28λ⁵,31λ⁵-dotriacontazacyclodotriacontane-2,5,8,11,14,17,20,23,26,29,32-undione
EINECS	Contact for details

Quality Control

Our Syringostatin A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and MS, NMR, and IR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment to support your critical research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity (Proteasome Inhibition Assay)	IC₅₀ provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.