Description

7-Oxo Staurosporine is a potent and selective derivative of the natural product staurosporine, a well-known protein kinase inhibitor. This compound is a critical research tool for studying cellular signaling pathways, particularly those involving protein kinase C (PKC) and other serine/threonine kinases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, neuroscience, and signal transduction research.

Application

• Biochemical Research: Used as a selective kinase inhibitor to probe the function of specific protein kinases in cell signaling cascades.
• Oncology Research: Investigated for its effects on cancer cell proliferation, apoptosis, and tumor growth inhibition in preclinical studies.
• Neuroscience Studies: Applied in research on neurodegenerative diseases and neuronal signaling pathways.
• Pharmacology & Drug Discovery: Serves as a key intermediate or reference standard in the development of novel kinase-targeted therapeutics.
• Cell Biology: Employed to study cell cycle regulation, differentiation, and other kinase-dependent cellular processes.
• Enzyme Assay Development: Used as a control or standard compound in high-throughput screening (HTS) assays for kinase activity.

Basic Information

Product Name	7-Oxo Staurosporine
CAS No.	125035-83-8
Molecular Formula	C28H26N4O3
Molecular Weight	466.54 g/mol
Synonyms	7-Oxostaurosporine; UCN-01; 7-Hydroxystaurosporine; NSC 638850; 5,6,7,13-Tetrahydro-8,9,10,11-tetramethoxy-13-methyl-7-oxo-5H-indolo[3,2-a]pyrrolo[3,4-c]carbazole; Staurosporine derivative UCN-01; 7-Oxo-staurosporine aglycone
EINECS	Contact for details

Quality Control

Our 7-Oxo Staurosporine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.