Description

Calphostin D is a potent, cell-permeable inhibitor of protein kinase C (PKC) and a perylenequinone natural product. This compound is of significant value in biochemical and pharmacological research for studying intracellular signaling pathways and cellular processes. It is primarily utilized by researchers and scientists in the biotechnology, pharmaceutical, and academic sectors for target validation, mechanism-of-action studies, and as a critical tool in cancer research.

Application

• Biochemical Research: As a selective inhibitor of protein kinase C (PKC) isoforms for studying signal transduction mechanisms.
• Pharmacological Studies: Used in cell-based assays to investigate the role of PKC in disease models, particularly in oncology research.
• Academic Research: A key tool compound in university and institutional labs for fundamental research in cell biology and biochemistry.
• Drug Discovery: Employed in high-throughput screening (HTS) and target validation within pharmaceutical R&D pipelines.
• Apoptosis Research: Used to study programmed cell death pathways where PKC activity is implicated.
• Reference Standard: Serves as an analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Calphostin D
CAS No.	124986-26-1
Molecular Formula	C44H40O12
Molecular Weight	760.79 g/mol
Synonyms	UCN-1028D; Calphostin D (UCN-1028D); NSC 693871; 1,6,8,13-Tetrahydroxy-3-(2-hydroxypropyl)-10-methoxy-4-methyl-7,10,12,14-tetrapentacyclo[9.5.1.11,9.13,8.02,9]heptadeca-2,4,6,8,11,14-hexaene-5,15-dione; Perylenequinone PKC inhibitor; PKC Inhibitor Calphostin D
EINECS	Contact for details

Quality Control

Our Calphostin D is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is strictly light-sensitive and easily oxidized; prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Dark green to black solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.