Description

Calphostin I is a potent, cell-permeable inhibitor of protein kinase C (PKC) and a perylenequinone natural product. Its primary value lies in its high specificity and potency as a research tool for studying signal transduction pathways, cellular proliferation, and apoptosis. This compound is essential for researchers and developers in the fields of pharmaceutical R&D, biochemical research, and cell biology, where precise modulation of PKC activity is required.

Application

• Biochemical Research: A critical tool for studying the role of Protein Kinase C (PKC) isoforms in cellular signaling pathways.
• Pharmaceutical Development: Used in target validation and screening assays for oncology and neurology drug discovery programs.
• Cell Biology Studies: Employed to investigate mechanisms of cell growth, differentiation, and programmed cell death (apoptosis).
• Enzyme Inhibition Studies: Serves as a reference standard for evaluating PKC inhibitor activity and specificity.
• Academic Research: Utilized in university and institutional labs for fundamental research in molecular biology and pharmacology.

Basic Information

Product Name	Calphostin I
CAS No.	124857-59-6
Molecular Formula	C₄₄H₄₀O₁₂
Molecular Weight	784.79 g/mol
Synonyms	UCN-1028A; Calphostin A; 1,6,8-Trihydroxy-3-(2-hydroxypropyl)-10-methoxy-7-(3-methyl-2-buten-1-yl)-4,9-perylenedione; 4,9-Perylenedione, 1,6,8-trihydroxy-3-(2-hydroxypropyl)-10-methoxy-7-(3-methyl-2-buten-1-yl)-; PKC Inhibitor Calphostin I
EINECS	Contact for details

Quality Control

Our Calphostin I is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Dark green to black solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.