Description

Calphostin B is a potent, cell-permeable inhibitor of protein kinase C (PKC), specifically targeting the C1 domain. This high-purity biochemical is essential for advanced life science research, enabling precise modulation of PKC-mediated signaling pathways. It is a critical tool compound for researchers in oncology, neuroscience, and cell biology studying cellular proliferation, differentiation, and apoptosis.

Application

• Biochemical Research: A primary tool for studying the structure, function, and inhibition mechanisms of protein kinase C isoforms in vitro.
• Oncology Studies: Used to investigate the role of PKC in cancer cell signaling, tumor progression, and as a potential target for therapeutic development.
• Neuroscience Research: Applied in studies of neurotransmitter release, synaptic plasticity, and neuronal survival where PKC activity is a key regulator.
• Cell Biology Assays: Employed to dissect signal transduction pathways involved in cell growth, differentiation, and programmed cell death (apoptosis).
• Pharmaceutical Screening: Serves as a reference standard or pharmacologic agent in high-throughput screening for novel PKC inhibitors.

Basic Information

Product Name	Calphostin B
CAS No.	124824-06-2
Molecular Formula	C44H40O12
Molecular Weight	760.79 g/mol
Synonyms	UCN-1028B; Calphostin B, PKC Inhibitor; 1,6,11,16-Tetrahydroxy-8,13,18,23-tetramethyl-2,7,12,17-tetrakis(3-methylbut-2-en-1-yl)-4,9,14,19-tetraoxatetrapentacosa-1,5,10,15-tetraene-3,8,13,18-tetrone; PKC Inhibitor Calphostin B
EINECS	Contact for details

Quality Control

Our Calphostin B is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the vial to reach room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Dark green to black solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.