Description

Cryptophycin CAS NO 124689-65-2 is a potent macrocyclic depsipeptide originally isolated from cyanobacteria of the genus *Nostoc*. This compound is of significant interest due to its exceptionally high cytotoxicity, functioning as a microtubule-disrupting agent that inhibits tubulin polymerization. It serves as a critical reference standard and research-grade biochemical for scientists exploring novel chemotherapeutic pathways. Primary users include pharmaceutical R&D teams, academic researchers, and biotechnology firms focused on oncology drug discovery and the study of natural product-derived antitumor agents.

Application

• Pharmaceutical Research & Development: As a lead compound or reference standard in the discovery and development of next-generation anticancer therapeutics.
• Mechanistic Studies in Cell Biology: Used to investigate the dynamics of microtubule assembly and disassembly, and to study mechanisms of apoptosis.
• Biochemical Assay Development: Employed as a control or standard in high-throughput screening (HTS) assays designed to identify new tubulin-targeting agents.
• Structure-Activity Relationship (SAR) Studies: Serves as a core scaffold for synthetic modification to develop analogs with improved potency, selectivity, or pharmacokinetic profiles.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology, natural product chemistry, and cancer pharmacology.

Basic Information

Product Name	Cryptophycin
CAS No.	124689-65-2
Molecular Formula	C35H48ClNO9
Molecular Weight	662.21 g/mol
Synonyms	Cryptophycin 1; Cryptophycin A; (3S,6R,10S,13R,16E,20S,23S,26R)-26-[(2S)-2-Azaniumyl-3-phenylpropanoyl]oxy-10-benzyl-3-[(2R)-2-chloro-3-phenylpropanoyl]oxy-6,13,20-tris(2-methylpropyl)-2,5,9,12,19,22-hexaoxo-16-(prop-1-en-2-yl)-1,4,8,11,18,21-hexaazacyclotetracos-16-ene-23-carboxylic acid; AR-A 0022AA; NSC 657989
EINECS	Contact for details

Quality Control

Our research-grade Cryptophycin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and integrity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as identity, purity, and impurity profile to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.