Description

Cryptophycin 46 is a potent synthetic analog of the natural cyanobacterial cytotoxin, Cryptophycin 1, designed for advanced research and development. This compound is of significant interest for its highly potent microtubule-depolymerizing activity and its potential as a lead structure for novel anticancer agents. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biotechnology companies engaged in oncology drug discovery and mechanism-of-action studies. The compound is supplied under the identifier CAS NO 124689-64-1.

Application

• Anticancer Drug Discovery: Serves as a high-potency lead compound and molecular tool for developing novel chemotherapeutic agents targeting tubulin polymerization.
• Biochemical Research: Used in in vitro studies to investigate mechanisms of apoptosis, cell cycle arrest, and microtubule dynamics in various cancer cell lines.
• Structure-Activity Relationship (SAR) Studies: A key intermediate or reference standard for synthesizing and evaluating new cryptophycin analogs to optimize potency and reduce toxicity.
• Preclinical Development: Employed in the formulation and efficacy testing of potential drug candidates in animal models of solid tumors.
• Pharmaceutical Reference Standard: Used as an analytical standard in quality control and method development for cryptophycin-based pharmaceutical products.

Basic Information

Product Name	Cryptophycin 46
CAS No.	124689-64-1
Molecular Formula	C43H58ClNO10
Molecular Weight	784.38 g/mol
Synonyms	Cryptophycin 46; (3S,6R,10S,13S,16R,19S,22S,25S,28S,31S)-25-[(2S)-2-[(2S,3S)-3-Chloro-2-hydroxy-4-phenylbutanamido]propanamido]-13,16,31-trimethyl-6,10,19,22,28-pentaoxo-3-propan-2-yl-1,4,7,12,15,18,21,24,27,30-decaoxapentacyclo[30.3.0.05,9.014,17.020,23]pentatriacontane-31-carboxamide; Arenastatin A analog; Cryptophycin-46
EINECS	Contact for details

Quality Control

Our Cryptophycin 46 is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring material integrity for critical preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.