Description

Thiazostatin A is a potent and selective inhibitor of histone deacetylase (HDAC), a key enzyme class involved in epigenetic regulation. This compound matters for researchers and developers as it provides a critical tool for modulating gene expression and studying cellular differentiation and proliferation pathways. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in oncology research, neurodegenerative disease studies, and the development of novel epigenetic therapies.

Application

• Epigenetics Research: Used as a reference standard and active compound in studies targeting histone deacetylase (HDAC) activity and chromatin remodeling.
• Oncology Drug Discovery: Serves as a lead compound or biochemical tool in the screening and development of novel anti-cancer agents that work through epigenetic mechanisms.
• Cell Biology Studies: Employed to investigate the role of HDACs in cell cycle control, differentiation, and apoptosis (programmed cell death).
• Neuroscience Research: Applied in models of neurodegenerative diseases to explore the potential of HDAC inhibition in neuroprotection and memory formation.
• Biochemical Assay Development: Utilized as a high-purity inhibitor to validate and optimize enzymatic assays for HDAC activity screening.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in biochemistry and molecular biology.

Basic Information

Product Name	Thiazostatin A
CAS No.	124508-94-7
Molecular Formula	C15H20N2O4S2
Molecular Weight	356.46 g/mol
Synonyms	Thiazostatin; FR901375; HDAC Inhibitor FR901375; (2S,4R)-4-Hydroxy-2-[[(2S)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-2-oxoethyl]thio]-N-[(1S)-1-phenylethyl]-4-thiazoleacetamide; L-731,742; Thiazostatin A (FR901375)
EINECS	Contact for details

Quality Control

Our Thiazostatin A is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.